In the Spotlight
New Model for Determining Chemical Exposures—To determine if a chemical is a danger to human health, toxicologists must know the potential hazards of the chemical and to how much of it people are exposed. To help determine the latter, SOT members John F. Wambaugh and Richard Judson, alongside colleagues, have developed a mathematical model to help predict which household and industrial chemicals people interact with the most. Using their model, the researchers analyzed 8,000 chemicals and found that some of the ones with the highest potential exposure levels have not been extensively studied. (11/11/14)
Quantitative Approach to Genetic Toxicity Can Aid Human Health—Genetic toxicity is the ability of substances or physical agents to damage cell DNA and/or chromosomes.
This damage can result in mutations that increase the chances of birth defects or disease such as cancer. To understand a substance’s genetic toxicity, it is important to identify the genetic toxicity point of departure (PoD), which helps researchers identify the doses and exposures of the substance that may pose a risk to health. New research by SOT members, among others, identifies a preferred approach for determining PoDs, which can be used for evaluating human health risk and regulatory decision making. (11/1/14)
New Framework for Assessing Chemical Alternatives—Before manufacturers, retailers, governments, and other concerned parties can swap out a chemical of concern from a product or process, the proposed alternative should be examined to determine any health or environmental concerns that may exist with it. Over the last two decades, a number of approaches and policies have developed for conducting this type of assessment, which led the US EPA to ask the National Academy of Sciences (NAS) to develop a comprehensive framework for making chemical substitution decisions.
SOT Member David C. Dorman served as the chair of the committee tasked with developing this new framework, which was recently released. The committee identified a 13-step process for considering chemical and non-chemical alternatives. (10/24/14)
PCBs and Fish Don’t Mix—Oregon faces a problem: New tests of Columbia River fish found elevated levels of PCBs.
When this happens, the state issues a fish advisory, but as SOT member David Farrer tells The Oregonian, these warnings can only go so far: “We have to acknowledge this is definitely an environmental justice issue. It's better to eat something and survive than to not eat at all.” With many local tribes and communities relying on fish for both economic and cultural purposes, everyone acknowledges that much work is still to be done to keep Oregon’s waters and fish safe and healthy. (10/8/14)
Early Wildfire Smoke Advisories Protect Health and Save Money—Wildfires can pose a threat to human health from the gases and fine particles present in the blazes’ smoke plumes.
SOT members at the US Environmental Protection Agency conducted research on when people are informed of potential health effects of smoke and the resultant economic impacts. They found that if citizens were informed of potential health impacts from a nearby wildfire and intervention procedures were put in place when fine particles in the air were on the lower side of the threshold, millions of dollars could be saved in terms of hospital visits for asthma and health failure, loss in productivity, and more. (10/1/14)
SOT Hosted a Luncheon Congressional Briefing on the Tools and Technologies for Toxicity Testing in the 21st Century.
CCT FutureTox—The Society Sponsored a Two-Day Workshop on FutureTox with more than 200 Professionals Attending.
Thomas: Bills Before Congress—A service provided by the Library of Congress which offers up-to-the-minute legislative information. Schedules for House, Senate, and Committee Hearings are also available. This site also provides access to the Federal Register, the official record of Congressional Activity.
Meet SOT’s Leadership
SOT is led by a group of full-time board members, called Councilors, who are elected by ballot by the full membership and who manage the affairs of SOT. Learn more about SOT’s leaders.
Issue and Position Statements
As part of the Society’s mission to build for the future of toxicology and to promote the recognition of Toxicology by increasing the reliance of policy, regulatory and corporate decision-makers on the science of Toxicology, SOT has developed a procedure for writing Issue Statements. This procedure takes precedent over the drafting of Position Statements because SOT represents many diverse audiences and our mission to external audiences is to present a balanced view of the science and ensure that all policy decisions on grounded on scientific information.
Briefings & Testimony
Toxicologist and scientists provide an important role in the implementation of science in regulatory and public policy decision-making. Learn more about SOT’s activities on Capitol Hill.
What Toxicologists Say
Several of SOT’s past presidents talked recently about toxicology and their experiences as members of SOT.
View what these toxicologists had to say.
The following series of articles are written by toxicologists who are members of the Society of Toxicology but do not necessarily represent the views of the Society. SOT has made every effort to provide the public with balanced, informational pieces to share our expert knowledge more broadly.
Signaling Mechanisms for Metabolic Dysfunction Following Low-Level Arsenic Exposures: From Mouse to Man
Deepwater Horizon Oil Spill
Inhaled Particles: From the Nose to the Brain?
Can All Those Chemicals Be Causing My Asthma?
Scientific, Regulatory, and Public Perspectives on the Credibility and Use of Alternative Toxicological Test Methods in a Legislative Framework
Breast Cancer As a Multifactorial Disease: Interaction of Genetics, Life Stage, and the Environment
21st Century Validation Strategies—One Size No Longer Fits All
Alternative Approaches to the Safety Assessment of Natural Ingredients and Extracts in Cosmetics
View the list of topics.