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SOT 2016 Annual Meeting Proposal Submission—Final Reminder
Event: Maximizing Your Postdoc to Land the Ideal Permanent Position: What Search Committees are Seeking across Employment Sectors
Date and Time: Wednesday, April 22, 3:00 PM Eastern Time (12:00 PM Pacific)
Mark your Calendars! The Postdoctoral Assembly (PDA) is hosting a career-focused webinar entitled “Maximizing Your Postdoc to Land the Ideal Permanent Position: What Search Committees are Seeking Across Employment Sectors.”
Forethought and preparation for the career transition is essential for postdocs to sell themselves and obtain an interview. How to sell your experiences and be a successful candidate are specific to each career track, as well as each position. Generalizing the three major sectors (academia, government, industry), we planned this webinar to discuss career transition strategies for postdocs and graduate students including how to be competitive for full-time employment, how to navigate across job sectors, and what to expect during a formal interview.
Hosted by PDA Secretary Karin Streifel, the webinar speakers will give guidance for preparation for transitioning from trainee status to a career position. A knowledgeable panelist from each employment sector, academia, industry, and government, will share his or her insight into the hiring process and offer advice for making a competitive application.
The objectives are to 1) give postdoctoral scholars insight into gaining the desirable qualifications and skills specific to each job sector and 2) how job seekers can enhance their applications to stand out to a search committee.
You learned how valuable SOT is through your participation in the 2015 Annual Meeting. We invite you to participate in this webinar and encourage you to join
SOT to continue to have access to professional and career development resources. The next application deadline is May 1.
Please join us to learn more about how to effectively plan and prepare for a successful transition from a postdoctoral position to permanent employment!
Karin Streifel, PhD
Dear SOT Members,
The next Scientific Liaison Coalition (SLC) Webinar will be held on Tuesday, April 28 from 11:00 am–12:30 pm ET USA. The webinar, "Gatekeeper and Watchman: the Microbiome Enters the Picture," will be presented by Ellen Silbergeld, Professor, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. The webinar will be moderated by Mary Alice Smith, SLC Representative for the Teratology Society, Professor, University of Georgia, Athens, Georgia.
Microbial communities are found at multiple human body sites. Collectively, an individual’s “microbiome” is now recognized as a key determinant in human health and well-being, including development. An individual’s microbiome is influenced by their lifestyle and environmental history. This raises new and provocative questions about the role of microbiota in commuting toxicological and epidemiological information.
This webinar will review the dual function of microbiota in such chemical-microbial interactions, providing specific examples that demonstrate the extent to which an individual’s microbiome affects exposure pathways (toxicokinetics) as “gatekeepers” at biological barriers to chemical exposure, and signaling pathways (toxicodynamics) as “watchman” of human health and well-being.
The research and professional activities of Dr. Silbergeld bridge science and policy, with a focus on the incorporation of mechanistic toxicology into environmental and occupational health policy. She also directs a Fogarty Training Program in Non-Communicable Diseases, which is a collaboration between Hopkins and the School of Public Health of Mongolia.
The mission of the SLC is “improving the ability of societies to partner with other domestic and international organizations that have objectives consistent with the goal of increasing the impact of the science of toxicology to improve public health” by:
SOT is a member of the SLC and as a member of SOT you are eligible to participate in this webinar. You must register to attend.
SOT is dedicated to creating a safer and healthier world by advancing the science and increasing the impact of toxicology.
You are receiving this correspondence as a service of your participation with the Society of Toxicology. Please contact SOT Headquarters if you have questions regarding these communications.
Your 2015 membership renewal is past due! Act now to reinstate your active status and retain your member benefits!
Dear SOT Members,
Thank you for being a member of the Society of Toxicology (SOT), the world’s foremost scientific society dedicated to advancing the science of toxicology. We hope to continue counting you as one of our partners in creating a safer and healthier world; however, your 2015 membership renewal is currently past due.
You may bring your membership up to date and reinstate your member benefits within minutes on the Membership Renewal page of the SOT website. Submit your 2015 membership dues securely by credit card or print an invoice to mail with payment (US Funds only). In the event that this message reaches you while your dues are already on their way to us, we thank you for renewing!
SOT membership provides many benefits, including:
Please contact SOT Member Services by email or call 703.438.3115 with any questions or if we may be of assistance. We value your participation in the Society and look forward to welcoming you back as an active member.
Clarissa Russell Wilson
Thank you for participating in the 54th Annual Meeting of the Society of Toxicology (SOT) in San Diego, California. I am pleased to report that this year’s meeting drew 6,900 attendees and 347 ToxExpo exhibitors, with nearly 170 sessions and over 2,800 presentations in all. As the President of SOT, I would like to offer you the opportunity to enhance your involvement with the Society by extending this personal invitation to apply now for membership.
As a nonmember attendee of this year’s SOT Annual Meeting, you are eligible to receive a dues waiver for 2015; once your application is submitted for review and approved by the SOT Membership Committee and SOT Council, you will not be charged any membership dues for the current year. This special offer provides a savings of $138 for Full and Associate members, $35 for Postdoctoral members, and $20 for Student members.
To take advantage of this 2015 dues waiver offer, use the easy online membership application form tosubmit your completed application by May 1, 2015. Should you require any assistance, please do not hesitate to contact SOT Membership Services by email or by phone at 703.438.3115.
By joining SOT, you demonstrate your commitment to being part of the leading global force in creating a safer and healthier world by advancing the science and increasing the impact of toxicology. As an SOT member, you will be able to access the members-only sections of the SOT website, including ToXchange, the private and secure SOT membership network; access and/or subscribe to the electronic and print editions of Toxicological Sciences1; join Specialty Sections and Special Interest Groups2; participate in your local Regional Chapter; use the SOT Job Bank job seeker services at no charge; submit abstracts for the Annual Meeting without a sponsor; and register for the 2016 SOT Annual Meeting in New Orleans, Louisiana at the preferred SOT member rate (about half the nonmember fee). Visit our website to learn of the many other benefits of SOT membership.
Once again, thank you for joining us this year in San Diego. We hope you found the meeting to be a valuable learning and networking opportunity, and we look forward to seeing you at the SOT 55th Annual Meeting next year in New Orleans, Louisiana.
Norbert E. Kaminski, PhD
SOT President 2014–2015
To Learn More and to Register, Visit www.toxicology.org/fda.
Dear SOT Members,
In 2015, the SOT Scientific Program Committee developed an impressive slate of timely and highly informative symposia, workshops, roundtables, and other special sessions that reflected the broad spectrum of topics of interest to our diverse membership. As a result of this programming, the Society will formally feature close to 2,900 presentations for its 54th Annual Meeting.
The number of presentations continues to underscore the growth of the meeting, and the unparalleled access to timely topics relative to toxicology. Therefore, we are excited to invite you to develop sessions for consideration for the 2016 Annual Meeting that will take place March 13–17, 2016 in New Orleans, Louisiana.
For the 2016 Annual Meeting, the Scientific Program Committee will be developing themes based on the accepted proposals. These program themes will be developed to highlight timely, topical areas in toxicology. All submissions are ranked and reviewed based on their timeliness and relevance to the field of toxicology. The proposal submission site is now open.
If you wish to submit a proposal for consideration, please continue collaborating with your Specialty Section, Special Interest Group, or the appropriate SOT Committee. Be advised that all groups that you would like to endorse your proposal should be contacted in advance of your submission and provided with a copy of the submission. This is an important step that allows these groups the opportunity to review, score, and rank the submissions before they are forwarded to the Scientific Program Committee for final evaluation.
The Scientific Program Committee held a webinar to discuss best practices for developing and submitting a proposal on Monday, March 9, 2015. A recording of this webinar is available on the SOT website.
We are looking forward to developing an exciting program from the proposals submitted for consideration for the 2016 Annual Meeting.
John B. Morris 2015–2016 SOT Scientific Program Committee Chair
Supplemental Training for Education Program
Deadline: May 15, 2015
SOT wants to award you with funding to pursue a professional/scientific educational activity necessary for you to achieve your career goals.
For previous awards, examples, and the application, visit the STEP web page.
The SOT bears the administrative expenses of the Endowment Fund, assuring that every dollar contributed goes directly to support programs. Consider making a contribution today and invest in the future of Toxicology. Make a donation today to the Society Endowment Fund as a symbol of your gratitude and your commitment to the future.
On behalf of the SOT Council, we wish to thank you for your participation in the Society of Toxicology (SOT) 54th Annual Meeting. As a valued attendee, it is important that we get your feedback on the overall quality of the scientific sessions and meeting. Therefore, we are asking that you take a few minutes to complete the 2015 Annual Meeting survey, and we would appreciate your response by April 10, 2015.
The SOT meeting is the premier event in toxicology. You make this meeting the important crossroads for toxicology that it is. We celebrate your contributions to our discipline that is so vital to making the world a healthier and safer place. Your continued feedback and involvement help us make additional strides as we move into the future.
See you in New Orleans, Louisiana, March 13–17, 2016!
Norbert E. Kaminski, PhD
Any 2015 SOT Annual Meeting attendees who participated in one or more of the five CME-approved sessions this week, and are interested in obtaining CME credits, are reminded to return their CME credit application forms to the SOT office (room 15) by 12:00 Noon on Thursday, March 26.
A basket for depositing the completed CME application forms was placed in the back of the CME session rooms, however if you completed your form after attending the session, please visit the SOT office with your completed form, so the application can be expedited.
Dear CE Attendee,
Thank you for selecting to advance your knowledge by participation in a 2015 SOT Continuing Education (CE) course on Sunday, March 22. All SOT CE courses will be held at the San Diego Convention Center. To facilitate locating your CE session room, please review and print the CE map of the convention center, which highlights the rooms in which courses will be held and the room locations. In addition, there will be directional signs throughout the convention center.
You may also download this map by using the SOT Mobile Event App.
Prior to leaving for San Diego, you are invited to download an electronic version of your CE course book by visiting the CE section of the 2015 Annual Meeting website.
Access to the electronic version (PDF format) of the CE course book(s) is based on your registration to the CE course(s). Please be aware that the electronic version of the course book is graphics-heavy, and may take a few minutes to download. The printed version of the book will also be available to all registrants upon arrival to your CE course room.
Following the CE courses on Sunday, we welcome you to access the Continuing Education Survey via the SOT Mobile Event App. Use the Survey icon in the Mobile Event App to gain access. You will be asked to enter a password. The case-sensitive password is sunshine15. The survey will also be sent to your email on Monday or Tuesday following the CE courses.
We look forward to seeing you in San Diego.
Norbert E. Kaminski, PhD
SOT 2014–2015 President
Thank you for registering to attend the 54th Society of Toxicology Annual Meeting and ToxExpo—the forum to showcase toxicology’s novel discoveries. For the science of toxicology, this five-day event is the culmination of a year’s worth of achievements in research and education. Below are the essential details for making the most of your Annual Meeting experience.
Scientific sessions are located in the San Diego Convention Center located at 111 West Harbor Drive, San Diego, California.
The SOT 2015 Annual Meeting Mobile Event App
This year we are happy to announce an enhanced Mobile Event App and Online Planner. These tools offer you multiplatform mobile solutions for the SOT Annual Meeting and ToxExpo, provided free of charge to attendees and exhibitors. The Mobile Event App and Online Planner are available via the SOT website and app marketplaces. These mobile tools enable you, the attendee, to engage with organizers, exhibitors, and each other, and to manage your time and maximize your experience while at the Annual Meeting.
The Mobile Event App allows you to:
The Online Planner features:
How Do I Install the App and Access the Online Planner?
iOS 6 and higher: Open the App Store and search for the app by entering SOT 2015. Press the Free or Install button.
Android 4 and higher: Open the Google Play app and search for the app by entering SOT 2015. Select Download and open the app after the download has completed. Developed for Android 4 and higher (older Android versions have very limited disk space and may prompt to delete other apps on the device before installing a new app).
Kindle Fire: From the Home screen, select Apps, select Store, and enter the SOT 2015 in the Search field. Select Free, then Get App to install.
BlackBerry (version 6.0+) or Windows Phone 7: Open the browser on the device. Navigate to http://ativ.me/sot15w
Online Planner: Access the Online Planner to build your custom schedule via the computer, download to print or sync with your iCal and/or sync to your device at any time. The Online Planner has optimal functionality using Chrome.
The Online Planner and Mobile Event App will prompt for a username and password before allowing users to access certain features, which include: “My Schedule” and “Attendee Messaging.” Only Annual Meeting registrants will have access to these restricted features. SOT Member registrants use their SOT membership login credentials for full access. SOT nonmember registrants use their email and password, which was used to register for the meeting to gain full access. At any time, use the password reminder on the SOT website login to have your password sent to your email address (the email address used to register for the meeting). Contact SOT Headquarters if you need assistance with your password.
View the App Overview: SOT 2015 Mobile Event App Overview
Staying connected before, during, and after the Annual Meeting is easy with SOT’s services and social media tools dedicated to sharing conference information. Throughout the week, the SOT website and the app will feature articles on sessions and events, testimonials, and meeting highlights. News also will be available via the ToXchange Communiqué blog, where members are invited to add comments. Members will receive daily notification of posted articles via their Favorites within ToXchange, either by email or through the mobile version of ToXchange. In addition, Tweeters can follow the SOT Annual Meeting and ToxExpo on Twitter at #2015SOT and #ToxExpo, also available from the Community feature within the app.
Interactive PDF of the Program and The Toxicologist
Many attendees recognize the added value of electronic versions of the Program and The Toxicologist. This year the enhanced Program PDF offers an electronic version of the printed piece and features easy-to-use navigation and robust search capabilities. PDF files are viewable and printable on virtually any platform, including Windows®, Mac OS, and mobile platforms such as Android (tablets and smartphones).
ToxExpo unites the world's leading scientists, executives, and decision-makers with exhibiting organizations featuring innovative, cutting-edge products and services. ToxExpo Exhibitors meet the demands of the discerning attendee providing unmatched industry knowledge and experience. Before you depart for San Diego, visit www.toxexpo.com and plan your visit!
|Monday||9:00 AM–4:30 PM|
|Tuesday||8:30 AM–4:30 PM|
|Wednesday||8:30 AM–4:30 PM|
If you have already received your badge, you do not need to wait in the registration line. If you have registered and have NOT received your badge by mail, or need a replacement badge, go the “Badge Pick-Up” counter of on-site registration in the San Diego Convention Center.
Registration Desk Hours
|Saturday||4:00 PM–7:00 PM|
|Sunday||7:00 AM–8:00 PM|
|Monday||7:00 AM–5:00 PM|
|Tuesday||8:00 AM–4:00 PM|
|Wednesday||8:00 AM–4:00 PM|
|Thursday||8:00 AM–12:00 Noon|
General Information Resources
As you prepare for your trip to San Diego, please keep in mind that additional general information can be found on the SOT 2015 Annual Meeting website:
San Diego Information
Air and Ground Transportation
SOT 2015 Annual Meeting Mobile Event App
Calendar and Maps
CE Course Map
If you have any questions, feel free to call us at 703.438.3115, Monday–Friday, 8:30 am–5:00 pm, EDT, or email SOT Headquarters.
We look forward to seeing you in San Diego!
The March 2015 issue of Toxicological Sciences includes an Editorial by Editor-in-Chief Gary W. Miller, Toxicology at the Speed of Light: An Interview with Dr. Craig Venter. Dr. Venter will deliver the Plenary Opening Lecture at the 54th Society of Toxicology Annual Meeting in San Diego, California on Monday, March 23, 2015, 8:00 am–9:00 am in the San Diego Convention Center, Hall D.
In his Editorial Dr. Miller notes about Dr. Venter that “He tackles big problems with aplomb, many of which no others dare approach. It is clear that he is a visionary scientist who continues to make major advances.” As the Editor-in-Chief of the official journal of SOT, he emphasizes the relevance of this Plenary Lecture to toxicology practitioners: “The field of toxicology likely does not need to invent entirely new technologies, but we do need to innovatively adopt and adapt emerging approaches to make them work to our ends. This is precisely what Dr. Venter has done throughout his career and meeting attendees are encouraged to attend what promises to be an inspirational and inspiring talk.”
Moreover, Dr. Miller will be available to meet with meeting attendees in the SOT Pavilion (Booth 526) Monday through Wednesday, March 23–25, 2015, from 10:00 am–11:00 am and 2:00 pm–3:00 pm. He is interested in hearing your responses to the redesigned journal and the addition of new features such as Look Inside ToxSci and the Contemporary Reviews in Toxicology.
As you develop your itinerary for the meeting, consider Dr. Miller’s closing comment about Dr. Venter: “As a scientist, Dr. Venter possesses extraordinary vision and his passion for science exudes from the pages of his books. I encourage you to attend his talk, read his books, and study his papers. The field of toxicology could use a few renegades.”
See you in San Diego!
Continuing with the objective of expanding Continuing Education (CE) offerings, SOT is pleased to announce four live webcasts to be held at the 54th Annual Meeting and ToxExpo™ on Sunday, March 22, 2015.
These four webcasts are part of the 2015 CE course roster, and are recommended for scientists who cannot attend the Annual Meeting in San Diego, as well as international scientists faced with travel restrictions.
These courses were carefully selected by the SOT CE Committee for worldwide topic appeal and shelf life. The four webcasts will be recorded and released as part of the SOT online CE program, CEd-Tox, in mid-2015.
The four webcasts offered on March 22, 2015:
AM05: The Future of Developmental and Reproductive Toxicology—Building a Bridge to the Animal Free Zone
(webcast begins at 8:15 am US Pacific Time)
AM06: The New World of Cancer Immunotherapy: Challenges in Bench to Bedside Translation
(webcast begins at 8:15 am US Pacific Time)
PM09: Interpretation of Cardiovascular Safety Data in Toxicology Studies
(webcast begins at 1:15 pm US Pacific Time)
PM13: Toxicogenomics Meets Regulatory Decision-Making: How to Get Past Heat Maps, Network/Pathway Diagrams, and “Favorite” Genes
(webcast begins at 1:15 pm US Pacific Time)
Webcast registrants will have access to the electronic book(s) for the course(s) they registered for approximately a week before the webcasts are presented on March 22, 2015.
For complete information on all 2015 CE courses and webcast registration, visit the 2015 SOT Annual Meeting website.
As a graduate student or postdoc registered for the upcoming Society of Toxicology (SOT) Annual Meeting in San Diego, we invite you to sign up to Chat with an Expert!
We have modified the registration this year in order to provide more complete information on the experts, including background information and preferred meeting dates (Monday through Thursday) in San Diego. Complete information on the revised Chat with an Expert registration process can be found on the SOT website.
In order to make it easier to find experts that best match with your interest, experts have been sorted based on their primary topic of research. You will also find the day they are available to meet during the week, which is important to keep in mind when you are selecting experts. Please choose the top three experts who you would like to meet with based on the code in the left hand column in the Expert Information document posted on the website, and then click the registration form to enter the codes for your experts. This year, you will also be asked to provide a few sentences about your background and research interests as well.
In the week to ten days leading up to the Annual Meeting, you can expect an email with the meeting location and contact information for your expert, as well as a brief survey that should be sent on to your expert. Every effort will be made to match students with their top choice in experts. GSLC reminds all graduate students and postdocs that the experts’ time is valuable during the Annual Meeting and if you are matched with an expert, please commit to meeting the expert at the designated time.
The deadline to register is Thursday, March 5, at 5:00 pm Eastern Time.
If you have any questions on Chat with an Expert, please contact Kelly Almond, the GSLC Programming Subcommittee Chair. Don’t miss your opportunity to expand your professional network and explore new career paths in toxicology!
Welcome to the electronic version of the Communiqué.
The links below will take you directly to one of the five sections of the newsletter.
The SOT bears the administrative expenses of the Endowment Fund, assuring that every dollar contributed goes directly to support programs. Consider making a contribution today and invest in the future of Toxicology.
If you’re not already registered, the Standard Registration deadline for the 54th SOT Annual Meeting is 11:59 PM (ET), Saturday, February 28, 2015.
The SOT Annual Meeting is the largest toxicology meeting in the world, with over 6,500 attendees and hundreds of vendor exhibits. Scheduled for March 22–26, 2015, in San Diego, California, the meeting is a cost-effective venue for high-quality scientific sessions and continuing education courses. If you have not already done so, please register now to take advantage of the reduced registration fees. After February 28, 2015, the On-site Registration rate will apply.
The Society of Toxicology (SOT) is pleased to offer the 2015 Continuing Medical Education (CME) program during the SOT Annual Meeting in San Diego, California. All CME sessions will be held on Sunday, March 22, Monday, March 23, and Tuesday, March 24.
AMA Designation Statement:
The UAMS College of Medicine designates this live activity for a maximum of 11.75 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Registration to the Annual Meeting will provide attendees with access to over 55 scientific sessions (Symposia, Workshops, Informational Sessions, Roundtables, Education-Career Development, and Regional Interest), all Poster and Platform Sessions, the Plenary and Keynote Medical Research Council (MRC) Lectures, ToxExpo™, and many other events held from Monday, March 23 to Thursday, March 26.
The SOT Continuing Education program kicks off the Annual Meeting on Sunday, March 22 (CE and CE/CME courses require additional registration).
The 2015 SOT CME Program:
Continuing Education (CE)/Continuing Medical Education (CME) Course (3.50 AMA PRA Category 1 Credits™ available): Skeletal System Endocrinology and Toxicology (PM11)
Sunday Afternoon, March 22, 1:15 PM to 5:00 PM
Chairperson(s): Alan M. Hoberman, Charles River Laboratories, Horsham, PA; and Susan Y. Smith, Charles River Laboratories, Senneville, QC, Canada.
The skeleton has traditionally been considered within the framework of two tenets: A hard structure for protection of the organism, and a major reservoir for the maintenance of serum calcium. Bone remodeling, the process of remaking our skeleton every decade, reinforces that structure/function correlate. However emerging evidence suggests the skeleton is intimately related to other organ systems including but not limited to organs involved in energy metabolism, reproductive system, immune system, central nervous system and muscle, through paracrine, endocrine and neural networks. The goal of this course is to explore these interactions further and highlight the importance of including skeletal evaluations in juvenile and standard toxicology studies and their relevance to humans and clinical trials. In addition, an overview of bone biology and the appropriate techniques for assessment of changes in bone will be provided. The presentations will focus on bone biology, its growth during infancy and childhood and the regulatory systems involved in the maintenance of bone quality during adulthood; the techniques available for bone evaluations in toxicology studies; why bone has recently been accepted as an endocrine system and what the functions of hormones secreted from bone are; and explore the complex relationships unfolding between bone and the different biological systems and the implications in drug development.
Complete information on this CE/CME course, including speaker biographies, available on the SOT website.
Workshop Session (2.75 AMA PRA Category 1 Credits™ available): Environmental Exposures and Alzheimer’s Disease: Epidemiology, Mechanisms, and Future Strategies
Monday Morning, March 23, 9:15 AM to 12:00 Noon
Chairperson(s): Jason R. Richardson, Robert Wood Johnson Medical School, Piscataway, NJ, and Anumantha Kanthasamy, Biomedical Sciences, Iowa State University, Ames, IA.
Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide and is expected to increase 3-fold over the next 40 years. To date, a massive amount of effort has focused on identifying genetic contributors to AD. Although there is a growing list of susceptibility genes that collectively contribute to AD, the largest GWAS study published on AD (>74,000 individuals) identified only 1 out of 19 loci as an individual strong contributor to AD. This finding has led to calls for studies to examine the potential influence of environmental and lifestyle factors on risk for AD. Given the wide-spread prevalence of AD and an ever-aging population, the role of environmental exposures in AD is a grossly understudied arena. This workshop brings together experts in the field of toxicology, neuroscience, and epidemiology to highlight the potential mechanisms by which environmental exposures contribute to AD. Experimental design and cutting edge technologies relevant to discerning environmental influences on AD will also be discussed. The workshop contains presentations and a roundtable discussion that will address five primary questions: (1) What epidemiological strategies are likely to provide the most robust information on the association between AD and environmental exposures?; (2) What information can we apply to AD from experiences studying the role of environmental exposures in other neurodegenerative diseases?; (3) What is the role of environmental exposures in the etiology of AD?; (4) Do epigenetic alterations represent a mechanism by which environmental exposure contribute to AD?; (5) Does regulation of protein aggregation and transport of pathogenic proteins by environmental exposures contribute to the progression of AD?
Workshop Session (2.75 AMA PRA Category 1 Credits™ available): Toxicological Epigenomics : The Interface between the Environment and Human Health
Monday Morning, March 23, 9:15 AM to 12:00 Noon
Chairperson(s): Shaun D. McCullough, Clinical Research Branch, US EPA, Chapel Hill, NC, and Dana Dolinoy, University of Michigan, Ann Arbor, MI.
An individual’s genetic makeup plays an important role in his or her response to toxicant exposure; however, polymorphisms in genes leading to susceptibility occur at a relatively low frequency. In addition to genetic makeup, epigenetic regulators, such as chromatin modifications, DNA methylation, and noncoding RNAs, function as critical and dynamic mediators of gene expression that shape the way that cells, tissues, and organisms respond to toxicant exposure. Toxicological epigenomics examines the role of these nongenetic mechanisms in the regulation of genes associated with toxicant response across the entire genome. By studying epigenetic mechanisms we will gain a better understanding of the molecular events underlying adverse health effects of toxicant exposure and improve our ability to predict susceptible populations. Further, the pliable nature of the epigenome allows for the use of epigenomics data to identify modifiable risk factors and develop models that will be used to limit the effects of toxicant exposure thus promoting human health. This workshop will examine epigenomic mechanisms that are associated with exposures and outcomes by bringing experts together to discuss the interplay of epigenomics and toxicant exposure in the context of environmental health. We will explore questions such as: (1) How can animal models be utilized in toxicoepigenomics research?; (2) How can human cross sectional, longitudinal, and clinical approaches best evaluate environmental effects on the epigenome and identify susceptible populations?; (3) How can epigenomic data be applied in risk assessment?; (4) How can toxicological epigenomics be applied to predict and mitigate the effects of toxicant exposure? Following this workshop, attendees will have a better understanding of how the epigenome influences the outcomes of toxicant exposure, how epigenomic studies can inform risk modification, and how epigenomics can be integrated into studies across many different aspects of toxicology.
Symposium Session (2.75 AMA PRA Category 1 Credits™ available): Local and Systemic Toxicity from Cobalt and Chromium-Containing Hip Prostheses
Tuesday, March 24, 9:00 AM to 11:45 AM
Chairperson(s): Allister Vale, School of Biosciences and College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, and Jeffrey Brent, University of Colorado Denver, Denver, CO.
Over 500,000 patients in the US have received a metal-on-metal hip prosthesis. Movement of loosened components in a failing prosthesis and friction between bearing surfaces can result in increased local and systemic metal concentrations, principally of cobalt and chromium. Metallic debris affects bone health through direct effects on bone cells and through indirect inflammatory signaling. These effects vary with the metal, its concentration, physical form, and valency. Cobalt and chromium localize at nuclear and perinuclear sites in osteoblasts, suggesting uptake through cell membrane transporters, and is modulated by P2 receptor blockade. Metallic debris induces a range of cellular responses by direct cytotoxicity mediated through activation of redox reactions or the substitution of other bivalent cations in biological pathways, and through cytokine induction that is potentiated by direct and indirect activation of inflammasome signaling. Clinical studies have demonstrated that cobalt causes cardiovascular, visual, auditory, and thyroid dysfunction; malnourished heavy drinkers, for example, develop cardiomyopathy. Eighteen patients with systemic toxicity in association with a metal-containing hip have been reported. The reported systemic features fell into three main categories: neuro-ocular toxicity (14 patients: peripheral neuropathy (six cases), sensori-neural hearing loss (seven), cognitive decline (five), ocular toxicity (six), cardiotoxicity (11 patients), and thyroid toxicity (nine patients). Currently, there is no evidence that chelation with any antidote will exert a beneficial therapeutic impact on clinical outcome in patients with health problems associated with cobalt containing hip prostheses.
Symposium Session (2.75 AMA PRA Category 1 Credits™ available): New Developments in the Management of Nerve Agent Poisoning
Tuesday, March 24, 1:30 PM to 4:15 PM
Chairperson(s): Allister Vale, School of Biosciences and College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, and Horst Thiermann, Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.
Nerve agents have been employed by Iraq and Syria and were released by terrorists in Japan on 11 occasions in 1994–5. These releases indicate that countries must be prepared to treat civilian as well as military casualties. This requires an understanding of the mechanisms of toxicity of these agents, the factors that influence their clinical impact and knowledge of potential treatments. Much research is underway to improve the current treatment regimens, which include an anticholinergic drug (e.g., atropine) to antagonize the effects of excess acetylcholine (ACh) at muscarinic effector sites, the use of an oxime to reactivate nerve agent-inhibited acetylcholinesterase (AChE) and an anticonvulsant benzodiazepine to prevent or stop nerve agent-induced seizures. A series of novel phenoxyalkyl pyridinium oximes that show efficacy in the brain have been tested and found to reduce brain AChE inhibition and attenuate seizures. The in-service (military) medical countermeasure provision is based on carbamate pretreatment; such an approach is not possible in the case of a civilian population who are also not likely to be wearing personal protective equipment (PPE). The concept of employing physostigmine, hyoscine, and HI-6 in a single autoinjector in the absence of any form of pretreatment may reduce incapacitation significantly. In addition, the potential of human recombinant butyrylcholinesterase alone, and in combination with standard therapy, as a postexposure treatment, and the use of antinicotinic drugs to reduce the effects of accumulated ACh, could offer additional benefits. Finally, a beta-cyclodextrin with an attached oxime function may offer an alternative approach by enhancing detoxification of nerve agents.
Complete information about these Symposia and Workshops available on the SOT website.
This activity has been planned and implemented in accordance with the requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of The University of Arkansas for Medical Sciences (UAMS) College of Medicine and the Society of Toxicology (SOT). The UAMS College of Medicine is accredited by the ACCME to provide continuing medical education for physicians.
The target audience for these courses are medical doctors, health professionals and researchers with an interest in clinical and translational toxicology, metals toxicology, neurotoxicology, risk assessment in medical practice, mechanisms, and occupational and public health.
The overall goal of this CE/CME course and the scientific sessions is to raise awareness and present clinically relevant toxicology of topics to physicians and pharmacists regarding:
Physicians-in-training (residents and fellows, and medical students) are eligible for special registration rates.
Additional registration required for the CE course.
CME Task Force:
Richard Y. Wang, DO (Chair)
William D. Atchison, PhD
John G. Benitez, MD, MPH
Michael Kosnett, MD
Melissa McDiarmid, MD, MPH
Martin A. Philbert, PhD
Kenneth S. Ramos, MD, PhD
Gary Rankin, PhD
John A. Wisler, PhD, DABT
The Society of Toxicology and Connections Housing (SOT’s official housing company) has been able to extend the housing reservation deadline to March 12, 2015. You may make new reservations, modify, or cancel existing reservations by using the online housing system or you may contact Connections Housing directly at 800.262.9974 or 404.842.0000, 9:00 am–7:00 pm ET Monday through Friday. You benefit when you book your hotel room within the SOT room block by receiving significantly reduced hotel rates and superior reservation services.
Between March 12–16, hotels will be downloading their lists and no changes can be made. After March 16, you will need to call the hotels directly to make any changes to reservations.
We look forward to seeing you in sunny San Diego!
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Dear Ms. Alvarenga,
We want you back!
We value your membership in the Society of Toxicology. However, to experience the full benefits of membership in the Society, you must be current in your membership dues. Take advantage of this special opportunity to reinstate your membership now without reapplying!
To resume active status as an SOT member, please remit payment for your 2014 and 2015 dues, which our records indicate are currently past due, by February 15, 2015. In the event that this message reaches you while your dues already are on their way to us, we thank you for renewing!
SOT membership provides many benefits, including an electronic ToxSci subscription, members-only access to the SOT website and ToXchange, free job seeker access to the SOT Job Bank, free use of the SOT Mentor Match program, reduced registration rates for premier toxicology meetings, the Communiqué newsletter, and more!
If you are planning to attend the SOT 2015 Annual Meeting in San Diego, California, please note that Standard Registration is in effect until February 28, 2015, after which Final Registration rates will apply. Your dues must be current in order for you to receive discounted member registration rates. (Your annual dues payment and member registration together are less than nonmember registration—this is a benefit of membership!)
For information on reinstating your membership, please contact Member Services or call 703.438.3115.
We look forward to welcoming you back as an active member of the Society.
Clarissa Russell Wilson
Your 2015 membership renewal is past due! Renew your SOT membership by February 15 to retain all your SOT member benefits.
Dear Ms. Alvarenga,
Thank you for being a member of the Society of Toxicology (SOT), the world’s foremost professional society dedicated to advancing the science of toxicology.
At this time, your 2015 membership renewal is past due. As we have noted in recent communications, failure to pay your membership dues by February 15, 2015, will result in suspension of your membership benefits. There is still time to bring your membership up to date by using the Membership Renewal page on the SOT website to renew now. You may submit your dues securely by credit card or print an invoice to mail with payment. In the event that this message reaches you while your dues are on their way to us, we thank you for renewing!
SOT values your membership and provides many membership benefits, including an electronic ToxSci subscription, members-only access to the SOT website and ToXchange, free job seeker access to the SOT Job Bank, free use of the SOT Mentor Match program, reduced registration rates for premier toxicology meetings, the Communiqué newsletter, and more!
If you are planning on attending the SOT 2015 Annual Meeting in San Diego, California, please note that Standard Registration is in effect until February 28, 2015, after which Final Registration rates will apply. Your dues must be current in order for you to receive discounted member registration rates. (Your annual dues payment and member registration together are less than nonmember registration-this is a benefit of membership!)
Please visit the SOT website to see if you qualify for the Membership Dues Assistance Program or 2015 Dues Waiver, note that as an additional benefit of membership in the Society, you may request retired status if you meet the following criteria:
Retired Membership. Those SOT members who have retired from active work in toxicology and earn less than 50% of their total income from toxicology-related work can send a letter of request for “retired status” making that statement to Council through the Executive Director‘s office. Retired members do not pay dues, but may choose to subscribe to the SOT journal at the member rate.
We look forward to receiving your membership renewal and continuing to partner with you as we work to create a safer and healthier world. If you have any questions or require any assistance, please contact SOT Member Services or call 703.438.3115.
Clarissa Russell Wilson
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The K–12 Subcommittee invites toxicologists to volunteer by February 15 for outreach activities in San Diego designed to increase knowledge about toxicology and encourage pursuit of careers in toxicology. SOT member volunteers are crucial to the success of these events.
In addition, if you know a high school student who has conducted research related to toxicology, please encourage this young toxicologist to participate in the High School Poster Exposition (HSPE). More details are below. You can also pass this information along to high school teachers you know.
We also want to know about K–12 outreach activities of SOT members. We’d really appreciate your providing details at K–12 Outreach Activity Report.
We especially thank the Southern California Regional Chapter for organizing two activities in conjunction with the meeting.
Tuesday, March 24, 10:30 AM–12:30 PM
ToxExpo Exhibit Hall, San Diego Convention Center
Attention High School Student Mentors—Travel awards available and Virtual HSPE! High school students can submit toxicology-related abstracts for consideration for the High School Poster Exposition and for travel support. The High School Poster Exposition is March 24, 2015 from 10:30 am–12:30 pm at the San Diego Convention Center and we have added a virtual component! The K–12 Subcommittee is able to offer a limited number of $500 travel awards for high school students whose abstracts are accepted for the HSPE. In addition, to include students who cannot travel to SOT, the K–12 Subcommittee will accept up to 15 virtual posters. SOT will print the posters for display on-site and presenters must be available during 10:30 am–12:30 pm PST to connect by web camera with the event. For more information, contact Betty Eidemiller.
Meeting attendees, the K–12 Subcommittee invites you to view the posters and support our young scientists! As high school students from the San Diego area and from around the country present their posters you will acknowledge these developing scientists’ accomplishments and encourage them to pursue careers in toxicology.
Saturday, March 21, 10:00 AM–5:00 PM
Petco Park, downtown San Diego
The Southern California Regional Chapter will host a booth at the free and largest annual southern California festival of science, technology, engineering, and math (STEM) education. What’s all the buzz about caffeine? Stop by “ToxTown” to test your caffeine trivia knowledge about beverages, food, and consumer products with added caffeine. Come play Tic-Tac-Tox, watch a specially-coordinated new “Risk Bites” YouTube episode. Chat with Andrew Maynard, creator of “Risk Bites” and recipient of the 2015 SOT Public Communications Award. Engage with toxicologists in other hands-on activities designed to foster an appreciation of the science and profession of toxicology. Bring your family to participate or volunteer to help build for the future of toxicology!
Wednesday, March 25, 11:00 AM–2:30 PM
Balboa Park, downtown San Diego
Meet at the Convention Center to travel to the nearby Greater San Diego Science and Engineering Fair, to assist the Southern California Regional Chapter in their annual tradition of selecting awards for students with outstanding projects related to toxicology.
Questions: Please contact Betty Eidemiller
You are invited to participate in the next colloquia developed by SOT and FDA Center for Food Safety and Nutrition (CFSAN) to advance food ingredient safety and food safety. The series presents scientific training that is high quality, cutting-edge, future-oriented toxicological science to provide a well-grounded, foundation to inform the work of employees in the FDA Center for Food Safety and Applied Nutrition (CFSAN). These colloquia are open to all scientists, policymakers, and others interested in toxicology related to food safety to attend onsite or via webcast. The colloquia are not designed to be a public forum for discussion of toxicology regulatory issues or to provide advice to the FDA.
Colloquium 2: February 23, 2015
Application of ADME/PK Studies to Improve Safety Assessments for Foods and Cosmetics—Harvey Clewell, Chair, The Hamner Institutes for Health Sciences, Research Triangle Park, NC
We need your help.
A few months ago, we shared a draft of the Hookah Issue Statement with you. Taking your comments and feedback into consideration, a revised version of the issue statement was developed and approved by SOT Council, becoming an official viewpoint of the Society.
As gratifying as it is to have the Hookah Issue Statement completed (a big thanks to the writing team of Judith T. Zelikoff, Terry Gordon, Anthony R. Schatz, Clive Meredith, Laura S. Van Winkle, and non-member Michael L. Weitzman), we would be remiss if we did not try to expose as many people as possible to the facts and information it contains. This is where we need your help.
Do you, your friends, your kids, your nieces and nephews, your students, or others you know use social media frequently? Are you a member of another society who would be receptive to our message? Would your employer be? If the answer is yes to any of these questions, please take a moment to share or ask others to share one of special hookah infographics we’ve created. View and download the graphics. Every person that we can get to share this information will help us fulfill our mission of creating a safer and healthier world.
And while you’re helping us on the social front, we’ll be distributing the information to newspapers and other traditional media—not to mention sharing it on social media ourselves, so feel free to share our posts if it’s easier than posting yourself.
Please join us in bringing more awareness to the health issues potentially associated with hookah smoking.
Norbert E. Kaminski
SOT President 2014–2015
SOT —Dedicated to Creating a Safer and Healthier World by Advancing the Science of Toxicology.
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