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Registration Desk Hours
General Information Resources
As you prepare for your trip to San Diego, please keep in mind that additional general information can be found on the SOT 2015 Annual Meeting website:
If you have any questions, feel free to call us at 703.438.3115, Monday–Friday, 8:30 am–5:00 pm, EDT, or email SOT Headquarters.
We look forward to seeing you in San Diego!
SOT—ToxSci Interview with Plenary Speaker J. Craig Venter
Welcome to the electronic version of the Communiqué.
The links below will take you directly to one of the five sections of the newsletter.
The SOT bears the administrative expenses of the Endowment Fund, assuring that every dollar contributed goes directly to support programs. Consider making a contribution today and invest in the future of Toxicology.
If you’re not already registered, the Standard Registration deadline for the 54th SOT Annual Meeting is 11:59 PM (ET), Saturday, February 28, 2015.
The SOT Annual Meeting is the largest toxicology meeting in the world, with over 6,500 attendees and hundreds of vendor exhibits. Scheduled for March 22–26, 2015, in San Diego, California, the meeting is a cost-effective venue for high-quality scientific sessions and continuing education courses. If you have not already done so, please register now to take advantage of the reduced registration fees. After February 28, 2015, the On-site Registration rate will apply.
The Society of Toxicology (SOT) is pleased to offer the 2015 Continuing Medical Education (CME) program during the SOT Annual Meeting in San Diego, California. All CME sessions will be held on Sunday, March 22, Monday, March 23, and Tuesday, March 24.
AMA Designation Statement:
The UAMS College of Medicine designates this live activity for a maximum of 11.75 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Registration to the Annual Meeting will provide attendees with access to over 55 scientific sessions (Symposia, Workshops, Informational Sessions, Roundtables, Education-Career Development, and Regional Interest), all Poster and Platform Sessions, the Plenary and Keynote Medical Research Council (MRC) Lectures, ToxExpo™, and many other events held from Monday, March 23 to Thursday, March 26.
The SOT Continuing Education program kicks off the Annual Meeting on Sunday, March 22 (CE and CE/CME courses require additional registration).
The 2015 SOT CME Program:
Continuing Education (CE)/Continuing Medical Education (CME) Course (3.50 AMA PRA Category 1 Credits™ available): Skeletal System Endocrinology and Toxicology (PM11)
Sunday Afternoon, March 22, 1:15 PM to 5:00 PM
Chairperson(s): Alan M. Hoberman, Charles River Laboratories, Horsham, PA; and Susan Y. Smith, Charles River Laboratories, Senneville, QC, Canada.
The skeleton has traditionally been considered within the framework of two tenets: A hard structure for protection of the organism, and a major reservoir for the maintenance of serum calcium. Bone remodeling, the process of remaking our skeleton every decade, reinforces that structure/function correlate. However emerging evidence suggests the skeleton is intimately related to other organ systems including but not limited to organs involved in energy metabolism, reproductive system, immune system, central nervous system and muscle, through paracrine, endocrine and neural networks. The goal of this course is to explore these interactions further and highlight the importance of including skeletal evaluations in juvenile and standard toxicology studies and their relevance to humans and clinical trials. In addition, an overview of bone biology and the appropriate techniques for assessment of changes in bone will be provided. The presentations will focus on bone biology, its growth during infancy and childhood and the regulatory systems involved in the maintenance of bone quality during adulthood; the techniques available for bone evaluations in toxicology studies; why bone has recently been accepted as an endocrine system and what the functions of hormones secreted from bone are; and explore the complex relationships unfolding between bone and the different biological systems and the implications in drug development.
Complete information on this CE/CME course, including speaker biographies, available on the SOT website.
Workshop Session (2.75 AMA PRA Category 1 Credits™ available): Environmental Exposures and Alzheimer’s Disease: Epidemiology, Mechanisms, and Future Strategies
Monday Morning, March 23, 9:15 AM to 12:00 Noon
Chairperson(s): Jason R. Richardson, Robert Wood Johnson Medical School, Piscataway, NJ, and Anumantha Kanthasamy, Biomedical Sciences, Iowa State University, Ames, IA.
Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide and is expected to increase 3-fold over the next 40 years. To date, a massive amount of effort has focused on identifying genetic contributors to AD. Although there is a growing list of susceptibility genes that collectively contribute to AD, the largest GWAS study published on AD (>74,000 individuals) identified only 1 out of 19 loci as an individual strong contributor to AD. This finding has led to calls for studies to examine the potential influence of environmental and lifestyle factors on risk for AD. Given the wide-spread prevalence of AD and an ever-aging population, the role of environmental exposures in AD is a grossly understudied arena. This workshop brings together experts in the field of toxicology, neuroscience, and epidemiology to highlight the potential mechanisms by which environmental exposures contribute to AD. Experimental design and cutting edge technologies relevant to discerning environmental influences on AD will also be discussed. The workshop contains presentations and a roundtable discussion that will address five primary questions: (1) What epidemiological strategies are likely to provide the most robust information on the association between AD and environmental exposures?; (2) What information can we apply to AD from experiences studying the role of environmental exposures in other neurodegenerative diseases?; (3) What is the role of environmental exposures in the etiology of AD?; (4) Do epigenetic alterations represent a mechanism by which environmental exposure contribute to AD?; (5) Does regulation of protein aggregation and transport of pathogenic proteins by environmental exposures contribute to the progression of AD?
Workshop Session (2.75 AMA PRA Category 1 Credits™ available): Toxicological Epigenomics : The Interface between the Environment and Human Health
Monday Morning, March 23, 9:15 AM to 12:00 Noon
Chairperson(s): Shaun D. McCullough, Clinical Research Branch, US EPA, Chapel Hill, NC, and Dana Dolinoy, University of Michigan, Ann Arbor, MI.
An individual’s genetic makeup plays an important role in his or her response to toxicant exposure; however, polymorphisms in genes leading to susceptibility occur at a relatively low frequency. In addition to genetic makeup, epigenetic regulators, such as chromatin modifications, DNA methylation, and noncoding RNAs, function as critical and dynamic mediators of gene expression that shape the way that cells, tissues, and organisms respond to toxicant exposure. Toxicological epigenomics examines the role of these nongenetic mechanisms in the regulation of genes associated with toxicant response across the entire genome. By studying epigenetic mechanisms we will gain a better understanding of the molecular events underlying adverse health effects of toxicant exposure and improve our ability to predict susceptible populations. Further, the pliable nature of the epigenome allows for the use of epigenomics data to identify modifiable risk factors and develop models that will be used to limit the effects of toxicant exposure thus promoting human health. This workshop will examine epigenomic mechanisms that are associated with exposures and outcomes by bringing experts together to discuss the interplay of epigenomics and toxicant exposure in the context of environmental health. We will explore questions such as: (1) How can animal models be utilized in toxicoepigenomics research?; (2) How can human cross sectional, longitudinal, and clinical approaches best evaluate environmental effects on the epigenome and identify susceptible populations?; (3) How can epigenomic data be applied in risk assessment?; (4) How can toxicological epigenomics be applied to predict and mitigate the effects of toxicant exposure? Following this workshop, attendees will have a better understanding of how the epigenome influences the outcomes of toxicant exposure, how epigenomic studies can inform risk modification, and how epigenomics can be integrated into studies across many different aspects of toxicology.
Symposium Session (2.75 AMA PRA Category 1 Credits™ available): Local and Systemic Toxicity from Cobalt and Chromium-Containing Hip Prostheses
Tuesday, March 24, 9:00 AM to 11:45 AM
Chairperson(s): Allister Vale, School of Biosciences and College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, and Jeffrey Brent, University of Colorado Denver, Denver, CO.
Over 500,000 patients in the US have received a metal-on-metal hip prosthesis. Movement of loosened components in a failing prosthesis and friction between bearing surfaces can result in increased local and systemic metal concentrations, principally of cobalt and chromium. Metallic debris affects bone health through direct effects on bone cells and through indirect inflammatory signaling. These effects vary with the metal, its concentration, physical form, and valency. Cobalt and chromium localize at nuclear and perinuclear sites in osteoblasts, suggesting uptake through cell membrane transporters, and is modulated by P2 receptor blockade. Metallic debris induces a range of cellular responses by direct cytotoxicity mediated through activation of redox reactions or the substitution of other bivalent cations in biological pathways, and through cytokine induction that is potentiated by direct and indirect activation of inflammasome signaling. Clinical studies have demonstrated that cobalt causes cardiovascular, visual, auditory, and thyroid dysfunction; malnourished heavy drinkers, for example, develop cardiomyopathy. Eighteen patients with systemic toxicity in association with a metal-containing hip have been reported. The reported systemic features fell into three main categories: neuro-ocular toxicity (14 patients: peripheral neuropathy (six cases), sensori-neural hearing loss (seven), cognitive decline (five), ocular toxicity (six), cardiotoxicity (11 patients), and thyroid toxicity (nine patients). Currently, there is no evidence that chelation with any antidote will exert a beneficial therapeutic impact on clinical outcome in patients with health problems associated with cobalt containing hip prostheses.
Symposium Session (2.75 AMA PRA Category 1 Credits™ available): New Developments in the Management of Nerve Agent Poisoning
Tuesday, March 24, 1:30 PM to 4:15 PM
Chairperson(s): Allister Vale, School of Biosciences and College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, and Horst Thiermann, Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.
Nerve agents have been employed by Iraq and Syria and were released by terrorists in Japan on 11 occasions in 1994–5. These releases indicate that countries must be prepared to treat civilian as well as military casualties. This requires an understanding of the mechanisms of toxicity of these agents, the factors that influence their clinical impact and knowledge of potential treatments. Much research is underway to improve the current treatment regimens, which include an anticholinergic drug (e.g., atropine) to antagonize the effects of excess acetylcholine (ACh) at muscarinic effector sites, the use of an oxime to reactivate nerve agent-inhibited acetylcholinesterase (AChE) and an anticonvulsant benzodiazepine to prevent or stop nerve agent-induced seizures. A series of novel phenoxyalkyl pyridinium oximes that show efficacy in the brain have been tested and found to reduce brain AChE inhibition and attenuate seizures. The in-service (military) medical countermeasure provision is based on carbamate pretreatment; such an approach is not possible in the case of a civilian population who are also not likely to be wearing personal protective equipment (PPE). The concept of employing physostigmine, hyoscine, and HI-6 in a single autoinjector in the absence of any form of pretreatment may reduce incapacitation significantly. In addition, the potential of human recombinant butyrylcholinesterase alone, and in combination with standard therapy, as a postexposure treatment, and the use of antinicotinic drugs to reduce the effects of accumulated ACh, could offer additional benefits. Finally, a beta-cyclodextrin with an attached oxime function may offer an alternative approach by enhancing detoxification of nerve agents.
Complete information about these Symposia and Workshops available on the SOT website.
This activity has been planned and implemented in accordance with the requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of The University of Arkansas for Medical Sciences (UAMS) College of Medicine and the Society of Toxicology (SOT). The UAMS College of Medicine is accredited by the ACCME to provide continuing medical education for physicians.
The target audience for these courses are medical doctors, health professionals and researchers with an interest in clinical and translational toxicology, metals toxicology, neurotoxicology, risk assessment in medical practice, mechanisms, and occupational and public health.
The overall goal of this CE/CME course and the scientific sessions is to raise awareness and present clinically relevant toxicology of topics to physicians and pharmacists regarding:
Physicians-in-training (residents and fellows, and medical students) are eligible for special registration rates.
Additional registration required for the CE course.
CME Task Force:
Richard Y. Wang, DO (Chair)
William D. Atchison, PhD
John G. Benitez, MD, MPH
Michael Kosnett, MD
Melissa McDiarmid, MD, MPH
Martin A. Philbert, PhD
Kenneth S. Ramos, MD, PhD
Gary Rankin, PhD
John A. Wisler, PhD, DABT
The Society of Toxicology and Connections Housing (SOT’s official housing company) has been able to extend the housing reservation deadline to March 12, 2015. You may make new reservations, modify, or cancel existing reservations by using the online housing system or you may contact Connections Housing directly at 800.262.9974 or 404.842.0000, 9:00 am–7:00 pm ET Monday through Friday. You benefit when you book your hotel room within the SOT room block by receiving significantly reduced hotel rates and superior reservation services.
Between March 12–16, hotels will be downloading their lists and no changes can be made. After March 16, you will need to call the hotels directly to make any changes to reservations.
We look forward to seeing you in sunny San Diego!
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Dear Ms. Alvarenga,
We want you back!
We value your membership in the Society of Toxicology. However, to experience the full benefits of membership in the Society, you must be current in your membership dues. Take advantage of this special opportunity to reinstate your membership now without reapplying!
To resume active status as an SOT member, please remit payment for your 2014 and 2015 dues, which our records indicate are currently past due, by February 15, 2015. In the event that this message reaches you while your dues already are on their way to us, we thank you for renewing!
SOT membership provides many benefits, including an electronic ToxSci subscription, members-only access to the SOT website and ToXchange, free job seeker access to the SOT Job Bank, free use of the SOT Mentor Match program, reduced registration rates for premier toxicology meetings, the Communiqué newsletter, and more!
If you are planning to attend the SOT 2015 Annual Meeting in San Diego, California, please note that Standard Registration is in effect until February 28, 2015, after which Final Registration rates will apply. Your dues must be current in order for you to receive discounted member registration rates. (Your annual dues payment and member registration together are less than nonmember registration—this is a benefit of membership!)
For information on reinstating your membership, please contact Member Services or call 703.438.3115.
We look forward to welcoming you back as an active member of the Society.
Clarissa Russell Wilson
Your 2015 membership renewal is past due! Renew your SOT membership by February 15 to retain all your SOT member benefits.
Dear Ms. Alvarenga,
Thank you for being a member of the Society of Toxicology (SOT), the world’s foremost professional society dedicated to advancing the science of toxicology.
At this time, your 2015 membership renewal is past due. As we have noted in recent communications, failure to pay your membership dues by February 15, 2015, will result in suspension of your membership benefits. There is still time to bring your membership up to date by using the Membership Renewal page on the SOT website to renew now. You may submit your dues securely by credit card or print an invoice to mail with payment. In the event that this message reaches you while your dues are on their way to us, we thank you for renewing!
SOT values your membership and provides many membership benefits, including an electronic ToxSci subscription, members-only access to the SOT website and ToXchange, free job seeker access to the SOT Job Bank, free use of the SOT Mentor Match program, reduced registration rates for premier toxicology meetings, the Communiqué newsletter, and more!
If you are planning on attending the SOT 2015 Annual Meeting in San Diego, California, please note that Standard Registration is in effect until February 28, 2015, after which Final Registration rates will apply. Your dues must be current in order for you to receive discounted member registration rates. (Your annual dues payment and member registration together are less than nonmember registration-this is a benefit of membership!)
Please visit the SOT website to see if you qualify for the Membership Dues Assistance Program or 2015 Dues Waiver, note that as an additional benefit of membership in the Society, you may request retired status if you meet the following criteria:
Retired Membership. Those SOT members who have retired from active work in toxicology and earn less than 50% of their total income from toxicology-related work can send a letter of request for “retired status” making that statement to Council through the Executive Director‘s office. Retired members do not pay dues, but may choose to subscribe to the SOT journal at the member rate.
We look forward to receiving your membership renewal and continuing to partner with you as we work to create a safer and healthier world. If you have any questions or require any assistance, please contact SOT Member Services or call 703.438.3115.
Clarissa Russell Wilson
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The K–12 Subcommittee invites toxicologists to volunteer by February 15 for outreach activities in San Diego designed to increase knowledge about toxicology and encourage pursuit of careers in toxicology. SOT member volunteers are crucial to the success of these events.
In addition, if you know a high school student who has conducted research related to toxicology, please encourage this young toxicologist to participate in the High School Poster Exposition (HSPE). More details are below. You can also pass this information along to high school teachers you know.
We also want to know about K–12 outreach activities of SOT members. We’d really appreciate your providing details at K–12 Outreach Activity Report.
We especially thank the Southern California Regional Chapter for organizing two activities in conjunction with the meeting.
Tuesday, March 24, 10:30 AM–12:30 PM
ToxExpo Exhibit Hall, San Diego Convention Center
Attention High School Student Mentors—Travel awards available and Virtual HSPE! High school students can submit toxicology-related abstracts for consideration for the High School Poster Exposition and for travel support. The High School Poster Exposition is March 24, 2015 from 10:30 am–12:30 pm at the San Diego Convention Center and we have added a virtual component! The K–12 Subcommittee is able to offer a limited number of $500 travel awards for high school students whose abstracts are accepted for the HSPE. In addition, to include students who cannot travel to SOT, the K–12 Subcommittee will accept up to 15 virtual posters. SOT will print the posters for display on-site and presenters must be available during 10:30 am–12:30 pm PST to connect by web camera with the event. For more information, contact Betty Eidemiller.
Meeting attendees, the K–12 Subcommittee invites you to view the posters and support our young scientists! As high school students from the San Diego area and from around the country present their posters you will acknowledge these developing scientists’ accomplishments and encourage them to pursue careers in toxicology.
Saturday, March 21, 10:00 AM–5:00 PM
Petco Park, downtown San Diego
The Southern California Regional Chapter will host a booth at the free and largest annual southern California festival of science, technology, engineering, and math (STEM) education. What’s all the buzz about caffeine? Stop by “ToxTown” to test your caffeine trivia knowledge about beverages, food, and consumer products with added caffeine. Come play Tic-Tac-Tox, watch a specially-coordinated new “Risk Bites” YouTube episode. Chat with Andrew Maynard, creator of “Risk Bites” and recipient of the 2015 SOT Public Communications Award. Engage with toxicologists in other hands-on activities designed to foster an appreciation of the science and profession of toxicology. Bring your family to participate or volunteer to help build for the future of toxicology!
Wednesday, March 25, 11:00 AM–2:30 PM
Balboa Park, downtown San Diego
Meet at the Convention Center to travel to the nearby Greater San Diego Science and Engineering Fair, to assist the Southern California Regional Chapter in their annual tradition of selecting awards for students with outstanding projects related to toxicology.
Questions: Please contact Betty Eidemiller
You are invited to participate in the next colloquia developed by SOT and FDA Center for Food Safety and Nutrition (CFSAN) to advance food ingredient safety and food safety. The series presents scientific training that is high quality, cutting-edge, future-oriented toxicological science to provide a well-grounded, foundation to inform the work of employees in the FDA Center for Food Safety and Applied Nutrition (CFSAN). These colloquia are open to all scientists, policymakers, and others interested in toxicology related to food safety to attend onsite or via webcast. The colloquia are not designed to be a public forum for discussion of toxicology regulatory issues or to provide advice to the FDA.
Colloquium 2: February 23, 2015
Application of ADME/PK Studies to Improve Safety Assessments for Foods and Cosmetics—Harvey Clewell, Chair, The Hamner Institutes for Health Sciences, Research Triangle Park, NC
We need your help.
A few months ago, we shared a draft of the Hookah Issue Statement with you. Taking your comments and feedback into consideration, a revised version of the issue statement was developed and approved by SOT Council, becoming an official viewpoint of the Society.
As gratifying as it is to have the Hookah Issue Statement completed (a big thanks to the writing team of Judith T. Zelikoff, Terry Gordon, Anthony R. Schatz, Clive Meredith, Laura S. Van Winkle, and non-member Michael L. Weitzman), we would be remiss if we did not try to expose as many people as possible to the facts and information it contains. This is where we need your help.
Do you, your friends, your kids, your nieces and nephews, your students, or others you know use social media frequently? Are you a member of another society who would be receptive to our message? Would your employer be? If the answer is yes to any of these questions, please take a moment to share or ask others to share one of special hookah infographics we’ve created. View and download the graphics. Every person that we can get to share this information will help us fulfill our mission of creating a safer and healthier world.
And while you’re helping us on the social front, we’ll be distributing the information to newspapers and other traditional media—not to mention sharing it on social media ourselves, so feel free to share our posts if it’s easier than posting yourself.
Please join us in bringing more awareness to the health issues potentially associated with hookah smoking.
Norbert E. Kaminski
SOT President 2014–2015
SOT —Dedicated to Creating a Safer and Healthier World by Advancing the Science of Toxicology.
© 2015 Society of Toxicology. All rights reserved.