Scientific Sessions

Scientific Program Overview (dates and times)

Symposium Sessions

• An Intelligent Reproductive and Developmental Testing Paradigm for the twenty-first Century
• Breast Cancer As a Multi-Factorial Disease: Interaction of Genetics, Life Stage, and the Environment
• Emerging Evidence for Novel Non-Cholinergic Mechanisms of Organophosphate-Induced Neurotoxicity
• Environmental and Occupational Factors: Adjuvant of the Immune Response
• Evaluation of Ocular Safety in the Development of New Drugs
• In Vitro and In Vivo Alternative Models of Developmental Toxicity of Pharmaceutical Compounds
• Nanoparticles for Drug Delivery: Interactions with the Immune System
• Nonclinical Safety Assessment of Dual Targeting Biotherapeutics
• Off the Beaten Path: Preclinical Approaches to Safety Evaluation of Cells/Gene Therapy, Vaccines, and Adjuvants
• Role of Trivalent Methylated Metabolites of Inorganic Arsenic in Toxic Effects by Arsenic Exposure
• The Allergenicity and Immunomodulatory Effect of Food Substances
• The Toxicological Impact of Metals, Crude Oil, and Chemical Dispersants from the Gulf of Mexico Oil Crisis on Human and Wildlife Health

Symposium Sessions: Thematic Track

Aberrant Gene Expression in Toxicity and Disease—Epigenetics and MicroRNAs

• Circulating MicroRNAs: A New Class of Biomarkers for Tissue-Specific Toxicity
• Epigenetic and miRNA Regulations in Carcinogenesis: Toxicological Implications
• Toxicological Considerations of Epigenetic Targets in Product Development

Characterizing Toxic Modes of Action and Pathways to Toxicity

• Cell Death Signaling Pathways and Mechanisms of Toxicity
• Cross-Species Analysis of Toxicogenomics Data: Approaches for Assessing Differences in Sensitivity and Conservation of Mode of Action
• DNA Damage Responses and Repair
• Molecular Basis for Prevention of Cardiotoxicity
• New Visions in Toxicology: Lysosomes—Roles in Disease, Toxicity, and Drug Development
• Realizing the Vision of twenty-first Century Toxicity Testing: Genetic Approaches to Pathway Analysis
• The Thick and Thin of Nuclear Receptors and Nrf2 in Diabetes and Obesity

Clinical Toxicology from Bedside to the Bench and Back

• Advances in Bridging Nonclinical Cardiovascular Data to the Clinic
• Dietary Supplement Adulteration and Impact on Human Health

Influence of Global Climate Change on Environmental Health Issues

• Emerging Mechanistic Targets in Lung Injury Induced by Combustion-Generated Particles

Regulatory Science: Bridging the Gap between Discovery and Product Availability

• Twenty-first Century Validation Strategies—One Size No Longer Fits All
• Development of Biosimilar Products: Overview of Standards and Regulations

Workshop Sessions

• Alternative Approaches to the Safety Assessment of Natural Ingredients and Extracts in Cosmetics
• Assessing the Bioavailability and Risk from Metal Contaminated Soils and Dusts
• Beyond Traditional Monoclonals: New Biologics Formats and Preclinical Challenges
• Biomarkers and Associated Health Consequences of Pesticide Exposures in Hispanic Populations
• Chemical Standardization of Botanical Medicines for Safe and Effective Use As Therapeutic Agents
• Cooperative Epidemiology and Toxicology Research: HEI’s National Particle Component Toxicity (NPACT) Initiative
• Progenitor and Stem Cells As Targets of Environmental Pollutants
• Sufficient Similarity of Whole Representative Mixtures or a Relative Potency Factor Approach: PAHs As a Case Study
• T-Dependent Antibody Responses in Non-Human Primates: Challenges and Opportunities
• Therapeutic Immunomodulation and Cancer Risk: Science, Risk Assessment, and Risk Communication

Workshop Sessions: Thematic Track

Characterizing Toxic Modes of Action and Pathways to Toxicity

• Caught in the Act: Free Radical Detection and Implications in Pathways to Toxicity
• Discovering Novel Hypotheses for Mechanisms of Toxicity from High-Content Data Sets
• How Useful Are Liver In Vitro Models for Toxicity and Mode-of-Action Prediction?
• Novel Topics in Environmental Polycyclic Aromatic Hydrocarbon Metabolism Leading to Carcinogenesis
• State of the Science and the Future for the Predictive Power of In Vitro and In Vivo Models for Nanomaterials Toxicity Testing
• The Epididymis: The Forgotten Target of Toxicants

Clinical Toxicology from Bedside to the Bench and Back

• Chelation Therapy: A Focus on the Risks and Benefits
• Muscle Toxicity—Current Challenges in Translatable Biomarkers
• Nonclinical and Clinical Applications of Translational Organ-Based Imaging
• Progress in Developing New Biomarkers of Drug-Induced Liver Injury (DILI): What You Don’t Know Can Hurt You

Regulatory Science: Bridging the Gap between Discovery and Product Availability

• Advancing Food Safety in a Global Marketplace
• Concepts Critical to the Next Generation of Human Health and Ecological Risk Assessment
• Evaluation of Allergenicity across Biotechnology Industries—Challenges and Opportunities
• High-Throughput In Vitro Toxicity Testing: A Mid-Course Assessment of Predictive Accuracy for In Vivo End-Points and Use in Decision Making

Roundtable Sessions

• Placing Bisphenol A Risks in a Human Exposure Context: Is Internal Exposure to Bioactive Bisphenol A in Humans Similar to Levels in Affected Rodent Test Species?
• Testing of Nanomaterials for Genotoxicity: Necessity or Waste of Time?
• The Future of Toxicology Education: Outcomes of the Toxicology Educational Summit

Roundtable Sessions: Thematic Track

Regulatory Science: Bridging the Gap between Discovery and Product Availability

• Evolving the EPA Endocrine Disruptor Screening Program: From Using High-Throughput Screening Assays for Prioritization to Reducing Reliance on Whole-Animal Tests
• Improving Chemical Safety Assessment through Harmonization: Why, How, and When?
• Scientific, Regulatory, and Public Perspectives on the Credibility and Use of Alternative Toxicological Test Methods in a Legislative Framework

Informational Sessions

• Evolution and Implementation of Combined Chemical Exposure Methods: International Perspectives
• Global Health and Environmental Impacts of E-Waste Recycling
• Good Laboratory Practice (GLP) in China
• NIEHS Centers for Nanotechnology Health Implications Research: Building Scientific Foundation for Evaluating Public Health Impacts of Engineered Nanomaterials
• Pregnancy in the Workplace: Managing Occupational Safety for a Unique Subpopulation
• Proposition 65: Twenty-Five Years of Implementing California’s Unique and Far-Reaching Law Regulating Organic and Metallic Carcinogens and Developmental/Reproductive Toxins
• Who Qualifies As a Toxicologist? Certification—Why, When, Where, and How

Education-Career Development Sessions

• Career Alternatives and Transitions: New Challenges and Opportunities in Today’s Job Market for Toxicologists
• Refining Your Science Communication Skills
• The Art of Negotiation: A Fundamental Skill for Scientists

Regional Interests Sessions

• Bridging the Green Chemistry Gap between Product Discovery and Availability
• What’s the Buzz? Bee Health and California’s Agricultural Industry